I'll second Thedude's statement about the hardest part being taxiing.
At max weight and flaps ten, Vr approaches 180 Knots. You will get up close and personal with the far end of a lot of 13,000 foot runways.
It's not as flexible in terms of slow down and go down as a 727, but better than the 737, and much better than the 757.
Joe
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