First off, congrats on your upcoming PhD - very well done!!! (I saw your post in another forum).
Secondly, it would most likely come up in a subsequent interview. But, so long as one had a good logical reason, I believe it'd be fine. What interviewers don't want to hear is about how one quit due to personal spite, scheduling problems, bad management, etc. If it comes downs to a personal reason, for example a dying airline, imminent layoff, and you quit in order to cut your losses and pursue something else and then decide to go back to the industry at a later date, I don't think it'd be much a problem in an interview. However, even this reason might require some sugarcoating.
Some other ramifications - if you quit, you don't have the lack of currency excuse that can be used by a furloughee. IOW, it behooves your resume to figure out a way to stay in the air as much as possible. Furthermore, unemployment becomes unavailable if you voluntarily quit. Therefore, most people without an underlying excuse would come to the sound conclusion to stick it out at a particular employer until either a layoff occurs or another opportunity comes available.
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