I don't mean to be short, terse, or otherwise negative but it's night cargo. Your question could receive as many answers as the number of those who choose to answer it. It works different for everyone.
As you can imagine the direct trade-off is QOL v. Pay. From what you posted it sounds like you'd want to sit in the back of 727 as long as possible to gain the most seniority, and thus, QOL.
I've been here around 5 years and have been in widebody right seat and backseat of the 727.
Good luck with your choice. Bottom line is unless you're really, really senior in your seat and/or live in domicile, you're going to probably be doing a lot of night flying/hub turns.