2/3 of a flight crew (usually looks like some flight instructor paired up with a retiree up front)
Most of the captains at my company, including myself, are in our thirties, and for just about all of us this is the second airline we've worked for. In my 2.5 years on the RJ I have flown with 1 FO who came straight from instructing. The pilots who come from PART 121/135 do just as well if not better than those from a corporate background. Also, the FAs at the regionals are generally friendlier and provide better service (for much less pay) then their counterparts at the majors.
The RJ is simply not meant for 2+ hour flights. It's a great airplane to take from ORD to GRB, but not DEN to ATL. Hince the name "regional" jet. Blame the airlines who schedule them on these long routes, not the airplane. And don't critisize flight crews who are often just as experienced and well trained as yourself!