I left a Fortune 500 corporate flight department two years ago to go to the majors. Most of the time I feel as though it was the right thing to do. The politics at play in corporate were incompatible with the size of my mouth...
I am back to making what I made there already (although they have been given substantial increases since I left that leave me in the dust). I have significantly more control over my schedule except on the holidays. I fly more now but work less. I miss corporate flying sometimes but I still say this was the right move for me and one that I should have made much sooner.