What is your tolerance for commuting? Some don't mind at all, some loathe it. Having done both throughout my career I'd rather switch companies and not commute. The drop in pay from starting over will be offset by the opportunities available living in base (Premium, OG, dropping trips for easy MU trips).
I moved to base last year. I had a pretty easy commute, 10 flights a day, 5 on us, usually Airbus. Loads were good, sat in the jumpseat less than 5 times a year. I spent 500 hours year getting to and from work. Seniority doesn't seem as important living in base. It doesn't really matter if my trips are commutable, doesn't matter if we get back late. I don't have to worry about weather the day my trip starts.
Reserve isn't so bad living in base.