Kind of depends on supply vs. demand and how many guard baby slots they have.
On one hand, everybody wants to do the airlines now, but OTH everybody just got a stark refresher on the old lesson that you should stay in the guard/reserve until retirement in case the airlines tank. You can do both, and most people do.
Age is working against you, so as otterbox said you need to rush with a vengeance... they need to like you, and you also need to convey that you're philosophically open to learning new tricks.
If you really want to do it, also look at USAFR. You can apply for UPT without affiliation to a specific unit, and get your aircraft and unit later. That might involve a commute obviously... you don't want to commute to both mil and airline, live in base for at least one of them.