I personally can't speak on this as I was never a 121 guy prior to coming here.
That said, I have plenty of friends here that did come from the regionals in the last year, and not a single one of them regrets it. That's not to say that several of them still aren't still looking for opportunities with the Majors/Legacies when the come comes, but literally none of them have said they wish they would have stayed at their regional.
YMMV