GreenDOG... what are your totals as far as flying goes? What is your current career experience?
With the copetition being so keen, if you are in the 1500 to 2000 band, you would have a better success with a regional carrier.
Before investing in any type rating be it on the B737, Airbus, or MD11, try to contact current FED EX and UPS employees. Don't rely on here say from others or second hand information, for the price can be very expensive and all you'll have is a type rating and no where to go.
If you do have previous 121 experience without an ATP then an initial type rating on let's say a B737 or Airbus may be worth your while if you meet the major carriers' average minimums. Carriers state what their minimums are... but the average minumums are greater than the company minimums.
Good luck and stay in the game... you'll be happier that you did.