I made the jump and am very happy that I did.
QOL is obviously a little worse for me being junior, but it wouldn't be that bad if I would live in base.
The crews are much more mature and experienced. Going from captain at the regionals to an FO at the majors, you can relax a bit more because the folks you're flying with have been flying for decades and know the ropes better than you (now you're the one they're keeping their eye on).
I really do enjoy the job. Going from a non-commuter to a commuter is really the only thing that I can complain about (and thats my choice and I knew it going in).
I would certainly make the move again.