Regional VS Major
Experience and guidance.
I don't think that regional pilots are inferior to anyone. They have a different job is all. Regional pilots usually get up earlier and work later flying as many as 9 legs a day in small under powered planes into small airports often using non-precision approaches.
Regional pilots also get paid much less for working harder and have to endure worse conditions like crummy hotels and criminal work rules. Put any pilot in those conditions and they will be at risk.
Skyhigh