Vaccine Development Summary
04-19-2021, 05:57 PM
#941
Prime Minister/Moderator
Joined APC: Jan 2006
Position: Engines Turn Or People Swim
Posts: 39,261
Originally Posted by Descendto450
I’m sure glad the U.S. didn’t waste Billions on that vaccine. From what I’ve been reading the Phizer and J&J are far more effective against the Brazilian and South African Strains..
I don't know if I'd give the USG much credit for that, how the mutations played out with various vaccines was not possible to predict. Policy, politics, and common sense dictated that we focus on western vaccines.
04-20-2021, 05:10 AM
#942
Gets Weekends Off
Joined APC: Mar 2020
Position: Airbus 320 Left
Posts: 254
Originally Posted by rickair7777
Sinovac had a lower efficacy to start with (which was fine in the beginning).
I don't know if I'd give the USG much credit for that, how the mutations played out with various vaccines was not possible to predict. Policy, politics, and common sense dictated that we focus on western vaccines.
I don't know if I'd give the USG much credit for that, how the mutations played out with various vaccines was not possible to predict. Policy, politics, and common sense dictated that we focus on western vaccines.
04-20-2021, 06:38 AM
#943
Perennial Reserve
Joined APC: Jan 2018
Posts: 11,498
Originally Posted by Descendto450
I agree with you on this one. I just remember last summer when this vaccine came out. We seemed so far behind..
The Chinese got it right off the bat....
04-22-2021, 06:53 AM
#944
Prime Minister/Moderator
Joined APC: Jan 2006
Position: Engines Turn Or People Swim
Posts: 39,261
Vaccine efficacy duration still unclear; general consensus is at least one year but less than lifelong...
https://www.newsnationnow.com/health...vaccines-last/
https://www.newsnationnow.com/health...vaccines-last/
04-22-2021, 07:59 AM
#945
Perennial Reserve
Joined APC: Jan 2018
Posts: 11,498
Originally Posted by rickair7777
Vaccine efficacy duration still unclear; general consensus is at least one year but less than lifelong...
https://www.newsnationnow.com/health...vaccines-last/
https://www.newsnationnow.com/health...vaccines-last/
Given that natural immunity for the four human coronaviruses that cause colds seems to only last nine months it was unlikely we were going to get much more than that out of a vaccine. 18 months maybe if we are lucky? But that’s only a guess and we won’t know until the time’s up. Right now we can only extrapolate a few months out. You don’t know for sure until it actually happens.
04-22-2021, 01:43 PM
#947
Prime Minister/Moderator
Joined APC: Jan 2006
Position: Engines Turn Or People Swim
Posts: 39,261
Originally Posted by Mesabah
The vaccines produce the antibody CR3022; That lasts about 9 months, I would expect the same, or slightly longer for the vaccines.
Technically, you can avoid the vaccine, and get the direct infusion if you have the cash.
Technically, you can avoid the vaccine, and get the direct infusion if you have the cash.
It's possible they might do a just-in-case booster before they know for certain, rather than risk lost efficacy in 100's of millions (billions?) of people.
04-22-2021, 01:50 PM
#948
Prime Minister/Moderator
Joined APC: Jan 2006
Position: Engines Turn Or People Swim
Posts: 39,261
Originally Posted by Excargodog
Given that natural immunity for the four human coronaviruses that cause colds seems to only last nine months it was unlikely we were going to get much more than that out of a vaccine. 18 months maybe if we are lucky? But that’s only a guess and we won’t know until the time’s up. Right now we can only extrapolate a few months out. You don’t know for sure until it actually happens.
04-22-2021, 02:02 PM
#949
:-)
Joined APC: Feb 2007
Posts: 7,339
Originally Posted by rickair7777
Your immune system will retain T-cells (aka memory cells) which will quickly mobilize your system to make the right antibodies on-demand. So efficacy duration is a combination of factors, including t-cell memory and response time, in addition to lingering antibodies. So the only way to know for sure is to wait and see, although the mfgs probably have a rough idea by now based on the blood-chemistry of the early-stage trial volunteers. But even that's not even the entire story, they really will need to collect real-world clinical data, as opposed to making the call based on lab chemistry.
It's possible they might do a just-in-case booster before they know for certain, rather than risk lost efficacy in 100's of millions (billions?) of people.
It's possible they might do a just-in-case booster before they know for certain, rather than risk lost efficacy in 100's of millions (billions?) of people.
Ideally, you want someone who is vaccinated to actually get Covid, as that produces a full immune response that lasts a long time. Maybe a future vaccine will change that, but for now, when the antibodies fade, there is no indication that your body will recognize the new Covid variants.
04-22-2021, 02:35 PM
#950
Prime Minister/Moderator
Joined APC: Jan 2006
Position: Engines Turn Or People Swim
Posts: 39,261
Originally Posted by Mesabah
You don't get T-cell memory with the vaccines,
If you got a mono-clonal antibody shot as you mentioned before, that would have no memory.
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