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Old 04-19-2021, 03:37 PM   #941  
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Iím sure glad the U.S. didnít waste Billions on that vaccine. From what Iíve been reading the Phizer and J&J are far more effective against the Brazilian and South African Strains..
Everything is a trade off. A year ago weíd have given a lot for it. And most people simply wouldnít believe the challenge that a -90 degree F freezer requirement is internationally. For airlines with a very significant international exposure - essentially the Big Three - this is a long way from over, and the ineffectiveness of ANY vaccine just drags it out longer...
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Old 04-19-2021, 05:57 PM   #942  
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Iím sure glad the U.S. didnít waste Billions on that vaccine. From what Iíve been reading the Phizer and J&J are far more effective against the Brazilian and South African Strains..
Sinovac had a lower efficacy to start with (which was fine in the beginning).

I don't know if I'd give the USG much credit for that, how the mutations played out with various vaccines was not possible to predict. Policy, politics, and common sense dictated that we focus on western vaccines.
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Old 04-20-2021, 05:10 AM   #943  
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Sinovac had a lower efficacy to start with (which was fine in the beginning).

I don't know if I'd give the USG much credit for that, how the mutations played out with various vaccines was not possible to predict. Policy, politics, and common sense dictated that we focus on western vaccines.
I agree with you on this one. I just remember last summer when this vaccine came out. We seemed so far behind..
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Old 04-20-2021, 06:38 AM   #944  
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I agree with you on this one. I just remember last summer when this vaccine came out. We seemed so far behind..
Well, it took the rest of the world a little time to learn how COVID spread was going to affect them.

The Chinese got it right off the bat....
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Old 04-22-2021, 06:53 AM   #945  
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Vaccine efficacy duration still unclear; general consensus is at least one year but less than lifelong...

https://www.newsnationnow.com/health...vaccines-last/
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Old 04-22-2021, 07:59 AM   #946  
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Vaccine efficacy duration still unclear; general consensus is at least one year but less than lifelong...

https://www.newsnationnow.com/health...vaccines-last/

Given that natural immunity for the four human coronaviruses that cause colds seems to only last nine months it was unlikely we were going to get much more than that out of a vaccine. 18 months maybe if we are lucky? But thatís only a guess and we wonít know until the timeís up. Right now we can only extrapolate a few months out. You donít know for sure until it actually happens.
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Old 04-22-2021, 10:08 AM   #947  
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The vaccines produce the antibody CR3022; That lasts about 9 months, I would expect the same, or slightly longer for the vaccines.
Technically, you can avoid the vaccine, and get the direct infusion if you have the cash.
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Old 04-22-2021, 01:43 PM   #948  
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The vaccines produce the antibody CR3022; That lasts about 9 months, I would expect the same, or slightly longer for the vaccines.
Technically, you can avoid the vaccine, and get the direct infusion if you have the cash.
Your immune system will retain T-cells (aka memory cells) which will quickly mobilize your system to make the right antibodies on-demand. So efficacy duration is a combination of factors, including t-cell memory and response time, in addition to lingering antibodies. So the only way to know for sure is to wait and see, although the mfgs probably have a rough idea by now based on the blood-chemistry of the early-stage trial volunteers. But even that's not even the entire story, they really will need to collect real-world clinical data, as opposed to making the call based on lab chemistry.

It's possible they might do a just-in-case booster before they know for certain, rather than risk lost efficacy in 100's of millions (billions?) of people.
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Old 04-22-2021, 01:50 PM   #949  
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Given that natural immunity for the four human coronaviruses that cause colds seems to only last nine months it was unlikely we were going to get much more than that out of a vaccine. 18 months maybe if we are lucky? But thatís only a guess and we wonít know until the timeís up. Right now we can only extrapolate a few months out. You donít know for sure until it actually happens.
Vaccine induced immunity *typically* is longer, and certainly more consistent across individuals, than natural immunity.
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Old 04-22-2021, 02:02 PM   #950  
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Your immune system will retain T-cells (aka memory cells) which will quickly mobilize your system to make the right antibodies on-demand. So efficacy duration is a combination of factors, including t-cell memory and response time, in addition to lingering antibodies. So the only way to know for sure is to wait and see, although the mfgs probably have a rough idea by now based on the blood-chemistry of the early-stage trial volunteers. But even that's not even the entire story, they really will need to collect real-world clinical data, as opposed to making the call based on lab chemistry.

It's possible they might do a just-in-case booster before they know for certain, rather than risk lost efficacy in 100's of millions (billions?) of people.
You don't get T-cell memory with the vaccines, they are not encoding the actual Covid19 spike protein, especially not the variants, as the actual one is not stable for production. It's SARs2(6ZP1). RCSB PDB - 6ZP1: Structure of SARS-CoV-2 Spike Protein Trimer (K986P, V987P, single Arg S1/S2 cleavage site) in Closed State They modified the virus spike protein to a stable version that has been studied for years.

Ideally, you want someone who is vaccinated to actually get Covid, as that produces a full immune response that lasts a long time. Maybe a future vaccine will change that, but for now, when the antibodies fade, there is no indication that your body will recognize the new Covid variants.
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