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Covid Treatment Development

Old 07-25-2021, 05:33 AM
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Default Covid Treatment Development

Japan-based Shionogi in trials of a pill-based covid treatment, intended to be taken once daily. Merck and Pfizer are already testing similar pill treatments.

Intended for home use to treat mild covid, similar to Tamiflu and similar OTC flu meds.

Current anti-retroviral treatments generally must be administer in a hospital setting.

Details on WSJ (link won't work due to paywall).
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Old 08-05-2021, 07:07 PM
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https://www.nejm.org/doi/full/10.1056/NEJMoa2109682

an excerpt:


Among household members who were confirmed to be both uninfected and without a recent history of infection, subcutaneous REGEN-COV prevented both symptomatic and overall SARS-CoV-2 infections, and the majority of participants who received this agent had minor or no adverse events. The relative risk reduction between the REGEN-COV group and the placebo group in the incidence of symptomatic SARS-CoV-2 infection was approximately 81%. Within 1 week after the initiation of REGEN-COV or placebo, the relative risk reduction was approximately 72%, which increased to approximately 93% after the first week. The relative risk reduction in high-viral-load infections (>104 copies per milliliter) was approximately 86%, and the relative risk reduction in all infections (symptomatic and asymptomatic) was approximately 66%. In participants in whom SARS-CoV-2 infection developed, those in the REGEN-COV group had a lower likelihood of symptoms than those in the placebo group. In the participants who became infected after receiving REGEN-COV or placebo and in whom symptomatic infection was confirmed, the duration of symptoms was 2 weeks shorter in the REGEN-COV group (in whom laboratory-confirmed symptomatic infection developed in 1.5%) than in the placebo group. Moreover, in participants in whom either symptomatic or asymptomatic infection developed, the magnitude and duration of detectable RNA (i.e., the peak viral load and weeks of RT-
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Old 08-16-2021, 08:55 AM
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Bio-marker identified which indicates long covid susceptibility. Study estimates about 25% of those infected experience long covid.

https://www.newsnationnow.com/health...d-study-finds/
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Old 08-20-2021, 02:23 PM
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Originally Posted by rickair7777 View Post
Bio-marker identified which indicates long covid susceptibility. Study estimates about 25% of those infected experience long covid.

https://www.newsnationnow.com/health...d-study-finds/
"The team plans to publish study results shortly." not published or peer reviewed. Nothing close to 25% of people I know that have been infected report any long term effect (other than continued aging - does that count?) I am still skeptical, no offense.
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Old 08-20-2021, 03:52 PM
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Originally Posted by skywatch View Post
"The team plans to publish study results shortly." not published or peer reviewed. Nothing close to 25% of people I know that have been infected report any long term effect (other than continued aging - does that count?) I am still skeptical, no offense.
It was an estimated number. I only knew two people who got covid 1.0 in 2020-2021, the young one had minor LC symptoms (and so did the spouse who also got it). The other person died, but she was very old and in end-of-life care anyway.

This month alone I have six friends and family who have the delta, too soon for any LC.
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Old 08-25-2021, 06:19 AM
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Anecdote alert: My aunt says that regeneron helped by elderly uncle a lot with delta. She also believes the vaccine helped him too because his covid progressed slowly. No way to know about that, but she's a doc.
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Old 08-28-2021, 05:56 PM
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Originally Posted by rickair7777 View Post
Japan-based Shionogi in trials of a pill-based covid treatment, intended to be taken once daily. Merck and Pfizer are already testing similar pill treatments.

Intended for home use to treat mild covid, similar to Tamiflu and similar OTC flu meds.

Current anti-retroviral treatments generally must be administer in a hospital setting.

Details on WSJ (link won't work due to paywall).
Also from Japan:

https://principia-scientific.com/jap...s-wonder-drug/
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Old 09-27-2021, 06:23 AM
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Pfizer doing stage 1 trials on an oral anti-retroviral. Looks like it's intended for early treatment or as a prophylactic in the event of exposure...

https://www.reuters.com/business/hea...ug-2021-09-27/
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Old 09-28-2021, 08:47 AM
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Pfizer submits data to FDA, believes the numbers look good for EUA for kids age 5-11.

https://www.newsnationnow.com/health...s-5-11-to-fda/
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Old 10-01-2021, 06:31 AM
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Merck "tamiflu" equivalent treatment cuts risk of hospitilization & death by 50% in trials...

https://www.reuters.com/business/hea...dy-2021-10-01/
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