Hey Kansas, with your corporate/charter background and experience, why dont you look into going into some other bizjet? depending on what you want with you career, you can get ridden at other places too, or you can go to a part 91 plane that flies you about 300 hours a year.....youve got many options (no pun intended, lol) man.......yes/no?

I wouldnt mind getting back into airline life... I think 121 is easier to operate under than 135...

I just wanted some heads up from folks in the "know"

Supplemental 121 ops are different than other 121's. Old equipment, no support and ending up somewhere and people ask you "what are you doing here?"
Its not rocket science, but it ain't that easy- 18 hour duty days and trying get some reasonable sleep being 8 different time zones away every few days gets old.