the a330 flies to hnd (tokyo), lax, las and sfo. it will soon fly kix (osaka) and sydney. the a330 and a350 is a fleet replacement for the 767s which will take place over the next decade. therefore, it will pick up current and new destinations as more deliveries arrive.
as far as being a takeover target...you may be right, we may be acquired. but its all rumors and hearsay. many airlines are in the same situation. should you avoid applying to an airline based on that information? what if hal is the acquirer? this industry is much too difficult to forecast beyond a few years. for now though, imho, its a pretty kick ass gig.