What is percieved as "depresion" in men can often be attributed to low testestrone level. Google "low testestrone" to read the symptoms. The next time your friend gets blood lab work, have them check. The problem is cured with suplements (patch or gel). If your friend is female, have her duscuss non-prescription suplements with Dr.
Caution - raising ones testestrone level can result in "over the top" posts on this network.