Originally Posted by Andy

I recommend that you apply to VX. Since I'm sure that you've got more than enough PIC from your flying frisbee time, move from an RJ to Fifi. Larger aircraft and experience in another type would be more valuable to you.
You mentioned that you live in DEN. I've commuted to/from SFO and it sucks due to weather issues. That alone will likely make you want to keep your resume/apps current.
If VX works out, great. You're there. If it doesn't work out, you can transition to another airline. I think going to VX is a much better choice for you than staying at a regional where you're getting right seat time.