Alcohol
Realistically pilots today probably should avoid all alcohol both on and off duty. Just too many ways to blow it. It takes a massive investment to get to an airline. One slip up on a day off can ruin decades of effort. Not worth it.
Don't forget FAR 91.17 While under the influence of alcohol. Not just drunk. Hung over counts too. 8 hours from bottle to throttle means a glass of wine at dinner not a bottle of whiskey then stop right at 8 hours prior to push. A swimmy head and pounding headache effects the safety of flight.
Skyhigh