My understanding:

Initially yes, but I think you can add trips back (during CIC window) that dont conflict with actual vacation but touch the C/O trip footprint.

If for example your C/O trip was a week long trip but was removed because your Vacation touched it on Sunday, you can add trips back that start on Monday. It is possible to add the same trip that was removed, If you are high enough up the cherry picking seniority list.