Doing a stint in the regionals is not always necessary. There are other ways to make it to a major/national airline as an old college friend just proved as he finishes IOE at Alaska.
Look at Ameriflight, work your way to the BE99 or the Metro, spend a year or two on that so you have the turbine PIC. Then get on with a corporate outfit and log the glass-jet time. If you end up going to a regional later, and you have 1000+ TPIC in the log book, now you can throw gear, grin and watch your resume get more competitive with each our of glass-jet, making the assumption you’re on an RJ, and wait for the windows of opportunity to open. 2 years at Ameriflight, a year on an RJ or a corporate jet and you are in position to competitively apply to some real airlines.
Two years on a BE99 at Ameriflight could prevent the seven year regional story. There are too many talented FO’s in the right seat that missed the waves of opportunity to upgrade and are stuck for years because they don’t have that PIC time. Hopefully the job market will take care of that. And the waiting continues.
Just another idea, I'll let the others bicker about who's the best one. Might as well find an olive for your martini in a jar of turds.
Good luck