Hardly anything is for certain. 5 minutes ago we thought that Mesaba was going to be gone, now they're going to be flying 900's for NW...
The only that is for certain is that the regionals all suck to a degree. You just have to figure out which one sucks the least for you.
I'll throw in another endorsement for living in base. If you can do it, it makes life so much easier and enjoyable...