He's 100% correct. The majority of aviation accidents of the last decade were all regional aircraft (turboprop and RJs). In fact, excluding 9/11, there was only one major airline crash (AA). There were many, many more regional aircraft crashes in that time period.

Part of the reason as already mentioned is the 5-6+ leg days, long hours, and short overnights. Fatigue comes into play, too. But lets not forget that (and I put myself in that boat because I was a low timer too) the regionals hire a majority of their FOs with less than 1,000 hrs, and many many more with less than 500 hrs. If time equates to experience, then you can easily argue a safer outcome will be in a more experienced environment (though not always the case).

Anyway, in conclusion, Sully is 100% right. Just look at Pinnacle's attempt to change the current policy of sending a pilot who fails a training event to the pilot review board for further training. Now it's back to the same ol' policy, and you better pass or lose your job. How is this a "safety-value"? It's the other advanced stuff too, like AQP at Delta. From what I hear it's far less stressful and more useful than the typical PCs at regionals where you simply check boxes and done. The level of safety at majors is different than the level of safety at regionals, because regionals are always trying to find the cheapest way of doing the absolute minimum and getting away with it.