Three step checklist:

(1) Find a phone
(2) Call Crew Scheduling
(3) Say whatever two magic words are necessary from the following list:

• I'm sick
• I'm fatigued
• I quit
• F U (will have the same effect as I quit)
• Whatever you do, don't be clever. A friend once asked a scheduler "does that jet have a pointy end? Good. Then use the pointy end and shove it ..." ALPA got him his job back after a year.

I'm kidding of course, but, people make mistakes when they are tired. Those who do safety work will all tell you that reserves tend to get in trouble after working several very long days when something else goes wrong (a distraction). Your passengers and the company deserve your efforts at your best. If you get pushed in the corner ... don't.

When I read the TA my thoughts were that the regional guys will instinctively respond to the "regional" like work rules with "regional" like defenses. The mission oriented folks will be in momentary conflict until they remember safety comes first.