Commuting is a function of senority, system form, and your distance (in time, not miles) to your domicle. If your junior, live in Bum *******, any where with three (off line jumpseats ) and five commutes a month, well..........
If on the other hand, you do one or two trips a month, you could live most places (cities) and not find commuting too intolerable. You could, depending on your employers system form, find your self home more than if you live in domicle if you fly out of your home town when your airline has to postion you to fly there anyway
Al this is dependent on, 1. how popular your home town is with other (company) pilots, senior to you, who are also are commuting to the same domicle, flying the same AC and flying the same seat as you. 2. How much flying at your home airport has trips that start with a dead head (or end, sometimes both (!!!) and wheather you can hold such trips (see above). 3. How senior in seat are you willing to get (fore going upgrades to hold/stay senior/protect your "good deal").
As you can see there is a lot to commuting that involves, where you work, where you live, luck (is the guys just senior to you living in the same area), and other factors related to how much your time (away from home) is worth to you, off the clock.
I hope this helps, (the wife advise in earlier posts is right on too)