Try setting up MS fight simulator on a flight from LAX to JFK in a transport category jet. Start at around 11PM your local time and fly it in real time the entire night. You can only get up three times during the entire flight for short five minute breaks. It must be accomplished in a dark room with the autopilot on for all but three minutes of the flight.
No TV. No radio. No phone. No iPad. No one to talk to. Do not sleep !! Just you staring at a dark unchanging screen for 6 plus hours. That is what it is like to fly for the airlines.
Boring
Uninspiring
Unrewarding

The best way to simulate it is to do that for at least three days in a row. Report back when you are done. If everyone had to do this before starting flight school and then had to study real airline pilot wages and trends we would have much fewer pilots around.
Skyhigh