I have flown 737 200/300 and /300 EFIS as well as 9 years on Sparky the Wonderjet. I'm back on Boeings (757) and I love it.

The bus is more comfortable and the flightdeck is better laid out and uncluttered. The sidestick is better than a yoke and the systems information on the Eicas is more complete than on the Boeing. It's a wierd philosophy - Airbus gives you all the information but you can't do anything about it. Boeing lets you do more system-wise but you don't have the systems synoptics available inflight.

But flying - hands down the vote goes to Boeing. More power, bigger wings, more rugged construction. Fly by wire takes a lot of feel out of the experience of hand flying. With the autopilot off your control inputs are still filtered through 7 flight control computers. You don't trim because that is done for you. And just as you get into the flare the flight control laws change. It makes for a challenging aircraft to fly well without the automation. But that's the crux of the problem - Airbus wants, nay DEMANDS that you use automation as much as possible. I rarely used the autopilot below 10000 but I always used the autothrust. Nonprecision approaches are managed through the FMS and must be flown on the autopilot until MDA. Lots of wierd quirks like that. Boeings are a lot more straightforward.