I'm not sure why you would "imagine" there's not much difference. A single engine approach in an MD-10-10 is a pretty big deal. It can barely get out of its own way with 3 engines. Losing 66% of your available thrust tends to be a big deal on any aircraft, IMO.

With an of the MD-11/-10 family a two-engine out approach is significantly different than just one engine out. It's a slats only approach, airspeeds are significantly higher, no auto-throttles during landing and no go-around option once the gear is down or the aircraft is below 1000' AGL.

Single engine out is a non-event in comparison. Normal flap settings and speeds and auto-land is even an option.