Depends on the airline. If they have a choice (ie enough bodies with ATP mins to fill the next class), some may prefer not to hire someone who is clearly major airline material.

In the case of SKW, we are crawling with ex-mil pilots, often retired O5/O6. They'll hire you, but will want to get some sense at the interview that you want to stick around at least for a while...for many that means roots in UT, ID, MT or even SOCAL, since a major airline newhire is almost certainly going to the east.