Three Strikes
Strike one Not an ex-military pilot. That is one strike against you.
Strike two You don't come from a prominent aviation family with strong ties in the airlines. That is strike two.
Strike three You have a DUI, are overweight, no college, older than most, took to long to upgrade, was fired during initial training at a regional, are not overly attractive, can not play golf, Lack people skills, HR gal was having a bad day and a huge number of other silly reasons that you can have your dreams rubbed out.
It is possible to get hired at a major with three strikes but not very likely. If anyone does a little research on new hire classes at the majors it becomes easy to find a pattern.
Skyhigh