I interviewed as a 1,000 hr CFI, and I was asked about the 3585 exemption. In my debrief I was told that it wasn't a huge knock on me for not knowing it, but "you want to work at a 121 carrier... you should be familiar with the regulations pertaining to it", so yeah I would be familiar with it. Know jepps really well. I was given an enroute chart and asked the standard "whats this mean". Then I was given an approach plate, and asked similar questions, followed by FAR questions. Wheres the FAF, whats the DA, if I see these lights can I land, what if the visibility drops inside the FAF..should I go missed, etc. Study high speed aerodynamics, know about mach tuck, swept wings, coffin corner, know how a jet engine works, axial flow compressor, whats N1 & N2 mean, etc. Know your most complex airplane's systems well. (Electrical, landing gear, etc.) If you study really hard for your interview, they can tell. Not only will this make you feel more prepared and confident, they will recognize this and ask fewer questions and/or move on to other things quickly.