PIC time always matters. Lets say you do get on with a major without PIC time. Then 2 years later, an economic downturn hits or your airline goes bankrupt and now you are furloughed on the street. Not very marketable without any TPIC time.

That being said I'm sure 99% of people would jump ship at a regional to a major without having PIC time. But it could come back to haunt them. Just a thought.