In the end, they are both pilots. I would hire the guy I would want to fly with every day. From my experience, it would be the twin otter guy. Regional pilots are usually totally miserable with their career choice. They would be the last guys I would want to bring in to my airline and "infect" my work force with. Yea, they can pass a 121 checkride (it ain't that big of a deal), but they bring a lot of luggage.