There is a slow trickle of people from Lakes going to Spirit, Frontier, and other second tier carriers. But there's an even greater number of jet RJ pilots with zero pic time going to these places as well (and several to United and Airways.)
The truth is, airlines have shifted their value to jet/FMS time, and in my case "aircraft weight" as I've been hired flying the NG overseas. Of course, if you're bumbling around as even a captain on the 1900 or 120, that opportunity isn't available unfortunately.
I have respect for the skills required to fly full procedures in the stated aircraft, but in terms of career progression, Lakes is more often than not a dead end.