Here's a good article about some of the early days of the U-2 program at Del Rio, TX. It talks about a few of the Cuban overflights during the Missile Crisis.

Remembering the Dragon Lady

"Two weeks into the crisis, tragedy struck the 4080th. Major Rudy Anderson, flying a U-2C was shot down by a SA-2. Some of the fragments of the missile’s exploding warhead penetrated his pressure suit and killed him.

Pilots at McCoy awaited his return, but they never saw him again. “I remember we were out on the golf course and Rudy never returned when we expected him. You could always see him in the traffic pattern from the golf course,” Brown recalls.

“When Rudy Anderson was shot down we all went ‘gulp,’” Brown says."