I used to own and fly a C337. When i did my first check ride with a Transport Canada inspector he asked me what engine, if any, was critical on the 337. Honestly I had not really thought about it. But, as he stated out of the regs, it is the engine that has the most adverse affect if lost. It's the back engine by the way. There is no aircraft body in front of any of the prop and it is in closer proximity to the elevator, therfore being more effective even at lower speeds.
And a normally loaded 337 on one engine flies like an overloaded 206. It's a very nice bird, cruises pretty good, hauls a decent load and get's in and out of some pretty knarly places. The thing should have a zero fuel weight frankly as with the pod and six seats you can load it up pretty well, as long as you're not going too far, but for doing air taxi in northern Manitoba it was perfect. All this for less then a Senaca I; the people you are flying just sometimes don't like the way it looks. It will also hold it's own in ice.