Get to the one that will give you the best QOL, if a major airline is your goal then that's what you need to pursue. Find the regional that is the best fit, good contract, good pay (ok, ok....better than bottom feeder pay) and a base that will hopefully work for the time being (they close all the time). Get in, learn something, get that PIC time, and get out while the getting is good...Now, back to your first question, but I'm not one to answer that.