In that regard, it becomes a lot like a helicopter vs a turboprop..

No assymetric thrust, but severely power limited.

I've flown the V-22 sim, not the actual bird and it was not too bad to fly (in the sim)

I can't speak to how the V-22 flies single engine, but I do know from flying larger turbine helos, that single engine landings to a single spot ship can get dicey with no waveoff capability below a certain altitude/airspeed.

IIRC (it's been a while) that if on glideslope, once I dropped below 45ish knots in a 60B single engine, I became more or less committed to land or crash anywhere near max gross. Losing an engine on takeoff was not as bad, but still hairy (had one actual engine failure once committed to forward flight, at night, and it kind of sucked as we were departing a Frigate)