I commute from PIT to SJU. Its not bad since there is one direct flight on weekends and its easy to get out of SJU. The biggest problem is trying to get a flight from PIT to PHL or CLT. Commuting between hubs can be tricky with hundreds of other pilots, FA's, gate agents and everyone else doing the same. But there are ways around it going to differnt cities or even ups and fedex. However, I have to give myself a 12 hour window each way otherwise the missed assignments would rack up real fast.