Only you can make the call. You have a big advantage in that your wife has one of the few high-paying jobs which are readily portable...I've told plenty of young pilots to stay single unless they can find a doctor or specialty nurse.

You might be at a "sweet spot", regionals are already having trouble filling classes. By the time you get there the majors should have ramped up hiring noticeably so you should move up relatively quickly (compared to the last decade).

Get on with Skywest on the EMB120 and you can drive to LAX or PSP. Your seniority should move up pretty quickly, right now you can get weekends and holidays off after a year or less. Then you could camp out until you upgrade at a relative seniority that works for you, and the majors should call shortly after. You could easily stay in SOCAL up until you get hired at a major and then maybe only a few years before you can make your way back west.

LAX may also end up as a junior base for Compass.

But don't waste any time if you're going to do it, the cost/payoff equation only gets worse as you get older.