Only you can decide. Before I made the return to aviation, my wife & talked about it and she supported me 100% in the move. It is a sacrifice, especially with children. A lot of this will depend on how you manage your time away from home and while you're at home. I recommend, when you are home, be home & when you are on the road, stay connected. The time that you have together with your family, make it count, go hiking, take photos, etc., things that won't drive you into debt, but will create fond memories. While we're on the topic of money, unless your wife has a good job or you have a side business, your resources will be quite strained for a number of years. If you and your family can agree to work through the difficulties of the life of a professional aviator. I've been truly blessed with a very supportive wife that keeps our children happy, even when they miss their father.
I hope this helps.