there's a pretty good chance their gonna ask about it, many individuals will think, how much "flying" were you doing while you were a safety pilot? Did being a safety pilot help your stick & rudder skills? Are you a better instrument pilot because you were the "safety" pilot in VFR weather doing instrument approaches? The way some of the regionals are getting right now, I wouldn't doubt if some of them are accepting safety pilot time in place of "SOME" multi-engine time, however, you'd have to be pretty darned close to their mins w/ regular multi before i'd even consider using 50 hrs multi- 50 hrs multi (safety pilot) time to get me in the door.