First of all, I do not believe there will ever be one piloted airliners for medical reason, even the healthiest people can have issues whether it be a serious medical issue or just a bad tired day where the pilot cannot operate the aircraft safely. One factor that must be considered is public perception, convincing the passengers that they are safe with an automated system flying them 35,000 ft in the air. I don't believe any automated system hasn't failed multiple times.