Depending upon the country, this is probably actually true. Departure taxes vary, but even if it's $75-80 out of someplace like Rome or Paris you've just cost yourself a whole reserve day's pay before you even get to work. Then you have the scheduling/days off/crashpad issues that have previously been mentioned. FAR 117 has made it more challenging to stack trips together than before so unless you can get your thirty hours off on a long overnight, you're destined to need a hotel or bunk so you can get your legal day off every week.

Commuting domestically is hard enough, the few people I know who do international (A) Don't mind being gone from home for two weeks at a time (B) Are very senior, and (C) Did not start as newhires making an international commute. If you're already well-established, off probation and off reserve and have some schedule control, and commuting to JFK or ORD, then maybe... Not having multiple flight options really will make it tough in the event of weather or a cancellation though, and if a flight is full/weight restricted, you may not make it home or to work at all. It is hard to argue that it is worth it. Throw in jetlag and fatigue, and yeah, the likelihood that you'll quickly come to loathe the job is practically guaranteed, and the chances that your marriage will not survive your career goes up tenfold. She may be homesick, but she'd also like to see you occasionally, yeah?