If you havn't flown since 2009 I'd get a flying gig. Anything is better than nothing but flying a 172 doesn't compete with a 121 job. But a Caravan bush flying, or night cargo, would help you tell a better story than flying a 172. Show desire to pursue this career. For whatever reason you stepped off the treadmill while thousands stayed on it. Be able to show, and tell, why you stepped off. Also be prepared to explain why you're back and what steps you've undertaken to be a career pilot.

Hoping that a major airline calls you, when you're 4-5 yrs non current, is a low probability position.

Timing is on your side since regionals are struggling to find candidates due to the 1500 hr rule. Good luck.