As long as you keep instrument current (IPC every 6 months), Landing currency (3 T/O & landing every 90 days), and bi-annual flight review within last 24 months, the regionals will at least offer you an interview. Then I would recommend you get a fresh IPC (in a multi-engine airplane) right before the interview. I personally know of several that where in your exact same situation and got hired by doing the above.