Financially speaking, it doesn't make sense. You probably make a decent paycheck on the ramp at a major. You need to save for retirement when you are young. Those are the most important years of saving. Do you have a bachelors degree? If you are serious about doing this then just get it done as fast as you can. A place like ATP would do it fast. Get your CFI and 1500 hours as fast as you can, get a job at a regional, and then wait your turn for a major. Without a degree you're more likely to end up at JetBlue or Spirit.