Where do you want to live? And is your family willing to live there as well?

ORD, MSP, IAH,...

Do you plan to sit in the right seat of an RJ for however long it would take you to have a similar schedule in the left seat? Do you plan on staying at a regional airline or are you hoping to get to a Legacy? If the latter is the case I'd start seriously reconsidering the profession if minimal time away from home is your goal.