Go with your gut, but do realize this: if you leave by choice, be grateful for that. My previous company was shut down, and the fear that generated--not to mention some of the anger and other emotions--was quite frightening. If you are able to control your own destiny, that alone is a blessing, and has to make this much easier.

I agree that getting back into the regionals will likely not be hard, even in several years. The downside is that you will be starting over if you do so, but if you are in such a position that the pay is not a hindrance at that time, then that too is a blessing.

Good luck, no matter what you do...