I went from Cape Air to regional. When I was instructing I got hired as an FO at Cape with about 700 hours. At the time no other regionals were hiring. I was also part of the Bridge program with JB, but at the time (and I think it's still true) you had to come from UND or Riddle. Cape Air was a great experience for me and I felt it was better getting my time there than continuing to instruct. However I do think that you would have to go to regional and wouldn't be able to go straight from Cape to major.