I don't really see how the LGBT issue would come up all that often. One problem you could run into, though, is having to put up with occasional intolerant comment in the cockpit. In less than one year with the airlines, I've heard more ignorance spewed from the mouths of captains than any other time in my life on the topics of race, disability, gender, sexual orientation. I suppose in those cases you just have to be the bigger person.